Your gut is in constant conversation with your metabolism. Akkermansia muciniphila is one of the most prevalent species in the gut microbiome — up to 4% of a healthy adult gut — and is found in higher levels in lean, healthy people. Not all Akkermansia is equal. UltraFlora® Healthy Weight features pasteurized MucT® — the exact strain and form studied in two randomized, placebo-controlled human trials published in Nature Medicine. Across these researches, MucT® was shown to: * Help keep weight off: 58% less weight rebound * Improve insulin sensitivity by 28.6%, reduce body weight by 5 lbs. and fat mass by 3 lbs., and reduce total cholesterol by 8.7% vs. placebo‡ Three clinically studied ingredients, each targeting a different mechanism — gut barrier integrity, metabolic signaling, and glucose metabolism:* * Pasteurized Akkermansia MucT® (30 billion TFU): Supports healthy weight maintenance, healthy metabolism, healthy glucose and insulin metabolism, cardiovascular health, and cholesterol levels already within the normal range* * Green Tea EGCG (100 mg): Supports weight maintenance in concert with a diet and exercise program* * Chromium Picolinate (200 mcg): An excellent source of chromium that helps maintain normal blood glucose levels and supports healthy glucose metabolism* Allergen Information Non-GMO | Gluten-free | Sugar-free | Dairy-free | Soy-free | No fillers | No preservatives | Vegetarian | No artificial colors | Plant-based | For GLP-1 users seeking nutritional support *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. † Pasteurized Akkermansia muciniphila MucT was shown to reduce the percentage of weight regained 6 months after weight loss compared to placebo. †† Shown in obese populations when pasteurized Akkermansia muciniphila MucT is used up to 24 weeks after diet-induced weight loss. Mount S, et al. Nat Med. 2026. ‡ Results from a proof-of-concept study in overweight/obese volunteers; body weight and fat mass changes did not reach statistical significance. Depommier C, et al. Nat Med. 2019. ★Based on 2024 study data from independent US survey showing which professional supplement brands are most recommended or sold by healthcare professionals. Professional-grade supplements are those typically sold through HCPs

Melatonin is produced primarily in the pineal gland but also in the bone marrow, platelets, GI tract, eyes, skin and lymphocytes. Its chemical precursor is serotonin, a neurotransmitter derived from tryptophan. Serotonin must be acetylated and methylated to form melatonin. Synthesis and production of melatonin is affected by light exposure to the eyes; serum concentrations of melatonin are typically low during the day hours and increase when dark. Since it has important effects in affecting circadian rhythms, melatonin has been reported to have significant effects on sleep-wake cycles and antioxidant function.

Motility in the GI tract describes the movement of food and other substances through the stomach, small intestine, large intestine and eventually out of the body. In between meals, the migrating motor complex (MMC) is a cycle of peristaltic movement that acts as an inter-digestive housekeeper of the GI tract. The MMC facilitates transport of indigestible substances and bacteria from the stomach and small intestine into the colon, inhibiting the backward migration of colonic bacteria and an overgrowth of bacteria in the small intestine. It has been shown that motility impairment typically results in small intestinal bacterial overgrowth (SIBO). This distinctive blend of bioactives promotes contractions in the migrating motor complex, helping to restore proper motility, which ensures the steady flow of food particles and bacteria through the small intestine. In addition, it provides support for improved digestion and relief from temporary gas, bloating and associated GI discomfort. Does Not Contain Gluten, corn, yeast, artificial colors or flavors.