Evening primrose oil has been used for many years as a rich source of the Omega-6 essential fatty acids Linoleic Acid (LA) and its derivative Gamma Linolenic Acid (GLA). Although GLA can usually be made from Linoleic Acid within the body, certain conditions block the function of the Delta-6-Desaturase enzyme that converts essential fatty acids into their derivatives.

Meta-Sitosterol™ 2.0 is a naturally derived vegetable preparation featuring enhanced levels of a balanced concentrate of plant sterols—2 grams per day—which may help to maintain healthy blood cholesterol levels already within the normal range. The National Institutes of Health recommends a healthy diet, along with the consumption of 2 grams of plant sterols daily, to promote cardiovascular health. Also features the active, preferred form of folate (L-5-methyltetrahydrofolate) to support healthy homocysteine metabolism and cardiovascular health.*

Melatonin is produced primarily in the pineal gland but also in the bone marrow, platelets, GI tract, eyes, skin and lymphocytes. Its chemical precursor is serotonin, a neurotransmitter derived from tryptophan. Serotonin must be acetylated and methylated to form melatonin. Synthesis and production of melatonin is affected by light exposure to the eyes; serum concentrations of melatonin are typically low during the day hours and increase when dark. Since it has important effects in affecting circadian rhythms, melatonin has been reported to have significant effects on sleep-wake cycles and antioxidant function.